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mavacamten will lower the level or impact of ethinylestradiol by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Keep away from or Use Alternate Drug. Progestin and ethinyl estradiol are CYP3A4 substrates. Mavacamten may well minimize systemic exposures of ethinyl estradiol and progestin, which can result in contraceptive failure or a rise